For research use only. Not intended for human consumption. All information is provided for educational purposes.
Introduction
AOD-9604 is a synthetic peptide fragment derived from the C-terminal region of human growth hormone (HGH), specifically amino acids 176–191. It was originally developed to isolate the fat-metabolizing properties of HGH without triggering the anabolic or IGF-1-stimulating effects associated with the full HGH molecule. This selectivity has made AOD-9604 a popular subject in metabolic and lipolysis research.
Mechanism of Action
AOD-9604 is believed to interact with beta-3 adrenergic receptors, which play a role in lipolysis (the breakdown of stored fat) and thermogenesis in preclinical models. Key research observations include:
- Lipolysis stimulation: AOD-9604 has been studied for its ability to promote fat breakdown in adipose tissue models without the metabolic side effects of full HGH.
- No IGF-1 stimulation: Unlike full HGH, AOD-9604 does not appear to stimulate insulin-like growth factor 1 (IGF-1) in research models, making it useful for isolated fat metabolism studies.
- Cartilage and joint research: Emerging preclinical research has explored AOD-9604's potential effects on cartilage repair and osteoarthritis models, expanding its research applications beyond metabolic studies.
AOD-9604 in Combination Research
AOD-9604 is frequently studied alongside GLP-1 receptor agonists. Researchers investigating multi-compound metabolic protocols often pair it with Semaglutide or Retatrutide to evaluate whether HGH fragment activity produces additive effects on lipid metabolism pathways when combined with GLP-1 receptor engagement.
Reconstitution Protocol
AOD-9604 is supplied as a lyophilized powder and requires reconstitution prior to use:
- Use bacteriostatic water (BW) as the preferred reconstitution solvent for extended vial stability.
- Determine your target concentration before adding solvent (e.g., 1 mL BW into a 5 mg vial = 5 mg/mL).
- Inject BW slowly along the vial wall — avoid direct contact with the peptide cake to prevent foaming.
- Gently swirl until fully dissolved. Do not shake or vortex.
- Use U-100 insulin syringes for accurate small-volume measurement in research dosing protocols.
Storage Guidelines
- Lyophilized: Store in a cool, dry location away from direct light. Refrigeration extends shelf life.
- Reconstituted: Refrigerate at 2–8°C and use within the manufacturer's recommended window. Do not freeze reconstituted solutions.
- Label each vial with reconstitution date and concentration for accurate research documentation.
Available Research Quantities
Frontline Peptides supplies AOD-9604 in 5 mg and 10 mg quantities. View current stock and pricing on the AOD-9604 product page.
Disclaimer
AOD-9604 is sold strictly for laboratory and research purposes. It is not approved for human or veterinary use. Frontline Peptides products are intended for use by qualified researchers in controlled laboratory settings only. Always follow your institution's safety and handling protocols.